Arul Mozhi Padmanabhan and Victor Arokia Doss (2024) Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol‑induced Cardiac Hypertrophic Murine Model. Synergistic Effects of Cinnamomum verum and Stingless Bee Honey on Isoproterenol‑induced Cardiac Hypertrophic Murine Model, 10 (4).

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Abstract

Objective: This study aimed to validate the synergistic effects of Cinnamomum verum (C. verum) barks and stingless bee honey (SBH)
against cardiac hypertrophy (CH). Materials and Methods: Isoproterenol (ISO-group II-30 mg/kg)-induced cardiac hypertrophic Wistar rats
were used in this study. Hypertrophic rats were treated using the reference drug losartan (LOS Group III: 50 mg/kg) and aqueous extracts of
C. verum barks and SBH (ACH Group IV: 250 mg/kg and 250 mg/kg). CH was characterized by electrocardiography, hypertrophic indices,
and biochemical estimations such as total glucose, protein, albumin, lipid profiles, cardiac marker enzymes, and histopathological studies.
Results: Rats received ISO had increased levels of glucose, protein, cholesterol, triglycerides, very low-density lipoprotein, and low-density
lipoprotein, coupled with decreased levels of albumin and high-density lipoprotein. These levels were restored to near normal when treated with
ACH extracts of the standard drugs. Contrary to the ISO-induced myocardial damaged hearts, ACH extracts had a profound effect compared
to LOS, which was also reflected in histopathological studies. Conclusion: These data explicitly reveal that the ACH have a synergistic
cardioprotective (antihypertrophic) effect.

Item Type: Article
Uncontrolled Keywords: Cardiac hypertrophy, Cinnamomum verum, isoproterenol, metabolism, stingless bee honey
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 12 Dec 2025 06:45
Last Modified: 12 Dec 2025 06:45
URI: https://ir.psgcas.ac.in/id/eprint/2589

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