Packialakshmi, B (2020) In Vitro Antioxidant, Anti-arthritic, and Anti-Cancer Activities of Cissus quadrangularis Stem Extract. In Vitro Antioxidant, Anti-arthritic, and Anti-Cancer Activities of Cissus quadrangularis Stem Extract, 10 (1). pp. 50-56. ISSN 2249- 1023

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Abstract

Cissus quadrangularis is traditionally used for the treatment of several inflammatory
disorders such as rheumatisms, wounds and tumours. In this study, the antioxidant, anti-inflammatory and
anticancer activities of methanolic extract from the stem of Cissus quadrangularis (CQME) were evaluated in
vitro. Five different solvents with different polarities (ethanol, methanol, ethyl acetate, petroleum ether and
distilled water) were used to extract different compounds from the stem of C. quadrangularis. Fourier
transform infrared (FT-IR) spectroscopy was performed to analyse the presence of functional groups.
Antioxidant activity of CQME was determined by measuring hydrogen peroxide (H2O2) radical scavenging
activities. The anti-inflammatory activity was studied using the inhibition of protein (BSA) denaturation assay
and the cytotoxic effects of CQME on MG63 cell lines were determined by MTT assay. Phytochemical
screening of CQME confirmed the presence of phytochemicals such as phenols, carbohydrates, proteins,
alkaloids, flavonoids, triterpenoids, saponins and steroids. The FT-IR spectral analysis revealed different
characteristic peak values with various functional compounds in CQME and it was shown to be excellent
scavenger of H2O2 radical. CQME exhibited significant dose-dependent anti-arthritic activity with the IC50
value of 170.78 µg/mL. Moreover, CQME displayed strong antiproliferative potential against MG63 cell line
and the IC50 was found to be 17.5 µg/mL. Thus from the present investigation, it could be inferred that
CQME exerted significant antioxidant, antiarthritic and anticancer effects. C. quadrangularis has a promising
potential to be used as a drug source for inflammation and cancer treatment. © 2020 iGlobal Research and
Publishing Foundation. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Anti-cancer, Anti inflammatory, Antioxidants, Cissus quadrangularis, Free radicals, Osteosarcoma.
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 26 Feb 2026 05:19
Last Modified: 26 Feb 2026 05:19
URI: https://ir.psgcas.ac.in/id/eprint/2655

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