Packialakshmi, B and Vairaprajaa, V (2019) ANTI-INFLAMMATORY AND ANTIOXIDANT POTENTIAL OF ABUTILON INDICUM: IN VITRO STUDY. ANTI-INFLAMMATORY AND ANTIOXIDANT POTENTIAL OF ABUTILON INDICUM: IN VITRO STUDY. pp. 141-147. ISSN 2277 –4572)

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Abstract

The aims of this study were to screen the phytochemical compounds and to evaluate in vitro antioxidant and anti-inflammatory activities in the ethanolic
extract of Abutilon indicum (EtAI) leaves. Abutilon indicum leaves were subjected under phytochemical screening using five different solvents (distilled
water, ethanol, acetone, petroleum ether and ethyl acetate) with different polarities. The flavonoid and phenolic content of EtAI was determined using
standard biochemical methods. EtAI was assessed for ABTS radical scavenging, hydroxyl radical scavenging, reducing power and nitric oxide radical
scavenging assays. We also analysed the anti-inflammatory potential of EtAI using the inhibition of bovine serum albumin denaturation assay.
Phytochemical analyses revealed the presence of alkaloids, phenols, flavonoids, proteins, carbohydrates, triterpenoids and saponins in EtAI. The total
phenolic content of EtAI was 5.82 mg CE/g of extract. The total flavonoid content of EtAI was 7.91 mg RE/g of extract. EtAI exhibited strong
scavenging activity in a concentration-dependent manner in all the scavenging assays. The EC50 of EtAI on ABTS, reducing power, hydroxyl and nitric
oxide radical were found to be 2.65, 1.94, 3.66 and 0.62 mg/ml, respectively. It also showed excellent anti-inflammatory activity (IC50 = 227 μg /ml).
Our findings provide evidence that the ethanolic extract of Abutilon indicum (EtAI) leaves possess anti-inflammatory activity and is a potential source
of natural antioxidants.

Item Type: Article
Uncontrolled Keywords: Abutilon indicum, Anti-inflammation, Antioxidants, Free radicals, FT-IR, Phytochemicals
Divisions: PSG College of Arts and Science > Department of Microbiology
Depositing User: Dr. B Sivakumar
Date Deposited: 26 Feb 2026 08:41
Last Modified: 26 Feb 2026 08:41
URI: https://ir.psgcas.ac.in/id/eprint/2657

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