Kunnathur Murugesan Sakthivel and Rasmi Rajan Radha (2025) Histone-Lysine N-Methyltransferase 2D (KMT2D) Impending Therapeutic Target for the Management of Cancer: The Giant Rats Tail. Histone-Lysine N-Methyltransferase 2D (KMT2D) Impending Therapeutic Target for the Management of Cancer: The Giant Rats Tail, 44 (1). pp. 31-36. ISSN 0731-8898

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Abstract

The histone-lysine N-methyltransferase 2D (KMT2D), tumor suppressor gene which is the major com-
ponent of histone H3K4 mono-methyltransferase in mammals and has significant role in regulation of a gene which are
frequently mutated that lead to many different types of cancers that include non-Hodgkin lymphoma, medulloblastoma,
prostate carcinoma, renal carcinoma, bladder carcinoma and lung carcinoma. KMT2D gene epigenetic alterations in
histone methylation play a significant role for the initiation and progression of cancers from pre-cancerous lesions, yet its
complete function in oncogenesis remains unsolved. KMT2D deficiency - loss are thought of initial mediators of cancer
development and cell migration such as B-cell lymphoma, medulloblastoma, melanoma, pancreas and lung cancer. The
KMT2D loss has know to activate glycolytic genes that promote aggressive tumor progression. Therefore, the present
review serves to underline the update on recent research pertaining to KMT2D gene, that could be a potential therapeutic
target in downregulating glycolytic genes such as Pgk1, Ldha, Pgam1 and Gapdh; 2, epidermal growth factor receptor
tyrosine kinase (EGFR-TK ) - ERBB2, RTK-RAS signaling, RAS activator genes Rgl1, Rasgrp1, Rasgrf1, Rasgrf 2 and
Rapgef5 in suppressing the tumor progression that may represent novel targeted therapy for the management of cancer.
This review will facilitate to understand the gene expression that inhibits cancer progression and which could serve as a
potential molecular target in understanding cancer pathogenesis.

Item Type: Article
Uncontrolled Keywords: KMT2D, lung cancer, methyltransferase, tumor suppressor gene
Divisions: PSG College of Arts and Science > Department of Biotechnology
PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 28 Feb 2026 09:08
Last Modified: 28 Feb 2026 09:08
URI: https://ir.psgcas.ac.in/id/eprint/2670

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