Kunnathur Murugesan Sakthivel and Rajan Radha Rasmi and Loganathan Chandramani Priya Dharshini and Kalavathi Murugan Kumar and Venugopal Vinod Prabhu and Balasubramanian Ramesh (2025) Nano encapsulated polymeric Scopoletin suppresses the progression of colorectal cancer by regulating cytokines and inflammatory mediators in AOM/DSS murine model. Nano encapsulated polymeric Scopoletin suppresses the progression of colorectal cancer by regulating cytokines and inflammatory mediators in AOM/DSS murine model. pp. 1-10. ISSN 0006-291X

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Abstract

Scopoletin (6-methoxy-7-hydroxycoumarin) belongs to the family of coumarins with numerous pharmacological
benefits. The present study deals with examining the efficacy of Nanoencapsulated polymeric Scopoletin (NEP-
Sc) in murine colon cancer model. Male Balb/c mice were supplemented with NEP-Sc (2.5 and 5 mg/kg b.w.) and
5-fluorouracil (25 mg/kg b.w.) for 10 days consecutively post-induction of colon cancer. Colon polyps and
morphology were assessed using a macroscopical inspection, and their score establishes the ameliorative effect of
NEP-Sc. Body weight, diarrhoea score, and spleen weight were also measured. The antioxidant status of the
mucosal levels of glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (LPO) and nitric oxide (NO)
were evaluated. The β-catenin and Ki-67 levels were analyzed through immunohistochemistry analysis to assess
the inflammatory response. ELISA-based analysis was used to measure IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma,
and VEGF levels. All the aforementioned parameters were mitigated in AOM/DSS-triggered colon cancer in mice
treated with NEP-Sc. Nanoencapsulated polymeric Scopoletin offered protection against AOM/DSS-induced
colon cancer in mice. To sum up, our research findings suggest that NEP-Sc may act as a promising candidate
for treating colon-associated cancer.

Item Type: Article
Uncontrolled Keywords: Scopoletin Antioxidants Inflammation Cancer Coumarin Colon cancer ELISA
Divisions: PSG College of Arts and Science > Department of Biochemistry
PSG College of Arts and Science > Department of Biotechnology
PSG College of Arts and Science > Department of Microbiology
Depositing User: Dr. B Sivakumar
Date Deposited: 28 Feb 2026 09:40
Last Modified: 28 Feb 2026 09:40
URI: https://ir.psgcas.ac.in/id/eprint/2672

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