Kunnathur Murugesan Sakthive and Sakthivel and Rajan Radha Rasmi (2025) Phytochemical Profiling, Antioxidant and Antimicrobial Activities of a Traditional Polyherbal Formulation Containing Citrus limon, Bergera koenigii, Citrus medica and Andrographis paniculata. Phytochemical Profiling, Antioxidant and Antimicrobial Activities of a Traditional Polyherbal Formulation Containing Citrus limon, Bergera koenigii, Citrus medica and Andrographis paniculata, 17 (3). pp. 881-895.

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Abstract

Background: Polyherbal formulations combining medicinal plants are widely studied for their
enhanced therapeutic potential. Materials and Methods: This study evaluates a polyherbal
formulation containing leaves of Citrus limon, Bergera koenigii, Citrus medica, and Andrographis
paniculata for its antimicrobic and antioxidative properties. An ethanolic extract was examined
to determine its phytochemical composition, which revealed a rich existence of bioactive
substances like bioflavonoids, alkali-like compounds, phenolics, and Steroidal glycoalkaloids.
Results: In vitro Total Antioxidant Capacity (TAC), including DPPH radical, FRAP and scavenging
of nitric oxide, exhibited significant radical-neutralizing capacities comparable to standard
antioxidants. The formulation also exhibited potent antibacterial action against strains of fungi
and bacteria, both gram-positive and gram-negative, suggesting a synergistic enhancement
of efficacy due to the combination of plant extracts. Conclusion: The outcomes highlight the
prospect of this polyherbal extract as a natural therapeutic agent to treat microbial infections
and oxidative stress. The future studies should focus upon in vivo evaluations and elucidating
molecular mechanisms to validate these promising results.

Item Type: Article
Uncontrolled Keywords: : Polyherbal Formulation, Phytochemicals, Oxidative Stress, Natural Therapeutics.
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 02 Mar 2026 03:32
Last Modified: 02 Mar 2026 03:32
URI: https://ir.psgcas.ac.in/id/eprint/2673

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