Kunnathur Murugesan Sakthivel and Rajan Radha Rasmi (2025) Chitin Derivative from Marine Source Artemia francis cana Cysts Inhibits Colorectal Adenocarcinoma Cells by Regulating Apoptotic Mediators. Chitin Derivative from Marine Source Artemia francis cana Cysts Inhibits Colorectal Adenocarcinoma Cells by Regulating Apoptotic Mediators, 17 (3). pp. 973-982.

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Abstract

Chitin is widely preferred in biomedical application due to its biocompatible
and biodegradable nature. Naturally occurring chitin is a potential antimicrobial agent and
plays a major role in degrading outer shell wall of the lower crustaceans. Naturally occurring
sources of chitin are more suitable for oncological research. Objectives: In the present study,
the chitin derivative isolated from marine source (Artemia franciscana cysts) is evaluated for its
potential to act as a therapeutic target for colorectal adenocarcinoma. Materials and Methods:
The FTIR and X-ray diffraction analysis of the isolated chitin has confirmed the presence of
characteristic functional groups such as amide groups, hydroxyl groups and glycosidic linkages
along with their material's crystalline structure. Results: The anticancer activity of extracted
chitin derivative showed significant cytotoxic effect in this study which could be attributed
to their positively charged functional groups. Further mRNA gene expression analysis has
revealed that the chitin derivative also exhibited apoptotic potential against HT29 cell lines by
upregulating caspase-3 and caspase-9 gene and by down regulation of B cell lymphoma-2 (Bcl-2)
gene expressions. Conclusion: In conclusion the present study showed that the Artemia
sp. cyst-mediated chitin derivative could be a potential anticancer agent against colorectal
adenocarcinoma through their anti-proliferative activity and by activation of apoptotic pathway
in HT29 cell lines.

Item Type: Article
Uncontrolled Keywords: Artemia, Cyst shell, Chitin, Anti-cancer, HT26.
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 02 Mar 2026 03:57
Last Modified: 02 Mar 2026 03:57
URI: https://ir.psgcas.ac.in/id/eprint/2674

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