Kunnathur Murugesan Sakthivel and Rajan Radha Rasmi (2025) Mechanistic insights into molecular targeted therapy and immunotherapy for lung cancer. Mechanistic insights into molecular targeted therapy and immunotherapy for lung cancer: 152204. pp. 1-13. ISSN 0006-291X

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Abstract

Lung cancer is a serious public health concern and a leading cause of cancer related deaths worldwide. The major
drawback of conventional therapies such as chemotherapy, radiotherapy, and surgery is their limited efficacy
and lack of tumor specificity. Of these treatment options, targeted therapy and immunotherapy are of best in�terest due to their potential to selectively target cancer cells and enhance immune responses. Targeted therapy
can bind to molecular targets and inhibit pathways involved in cell growth, proliferation, and survival. In the
case of lung cancer, targeting expressions of EGFR, KRAS, and BRAF are important as their overexpression makes
up a significant portion of cancer cases. Targets in the MAPK, PI3K, and MYC pathway are also inhibited as each
of these pathways promote cell proliferation and growth. Immunotherapy directly kills off cancerous cells by
amplifying the behavior of immune cells. Immunotherapeutic targets include NK-cells, T-cells, and immune
checkpoints. NK cells and T cells are involved in the elimination of cancer cells, while immune checkpoints
regulate the immune system but may be exploited by cancerous cells. The advent of molecular targeted therapy
and immunotherapy has significantly transformed lung cancer treatment, offering precision and efficacy in
combating tumor resistance. Their integration in combination strategies holds great promise for improved
clinical outcomes and represents a pivotal direction for future therapeutic advancements.

Item Type: Article
Uncontrolled Keywords: Lung cancer Targeted therapy Immunotherapy Molecular targets
Divisions: PSG College of Arts and Science > Department of Biotechnology
PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 05 Mar 2026 06:08
Last Modified: 05 Mar 2026 06:08
URI: https://ir.psgcas.ac.in/id/eprint/2678

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