Kunnathur Murugesan Sakthivel (2025) Quinoxaline from Marine Mangrove (Rhizophora apiculata) Exhibits Anti-Metastatic Potential against B16F-10 Melanoma Cellsin In-Vitro and In-Vivo Models. Quinoxaline from Marine Mangrove (Rhizophora apiculata) Exhibits Anti-Metastatic Potential against B16F-10 Melanoma Cellsin In-Vitro and In-Vivo Models, 11 (23). pp. 3863-3876. ISSN 2229-7359

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Abstract

Background: Lung cancer remains the leading cause of cancer related mortality worldwide, with non-small cell lung
carcinoma (NSCLC) representing the most prevalent and aggressive subtype due to its high metastatic potential. Despite
therapeutic advances, current treatment options are often insufficient, underscoring the need for novel anti-metastatic
strategies.
Objective: This study investigates the anti-metastatic potential of a quinoxaline in a B16F-10melanoma-induced
experimental lung metastasis model in BALB/c mice.
Methods: Mice were administered quinoxaline (10 mg/kg body weight, intraperitoneally), and its effects on lung metastasis,
survival, biochemical markers and matrix metalloproteinases (MMPs) were assessed. Molecular docking studies were also
performed to evaluate the compound’s interaction with MMP-2 and MMP-9.
Results: Quinoxaline treatment resulted in a significant reduction (p < 0.01) in the number of lung metastatic nodules and
enhanced survival rates in treated mice. The compound effectively restored the levels of metastatic biomarkers, including
hydroxyproline, uronic acid, hexosamine, gamma-glutamyl transpeptidase (GGT), nitric oxide (NO) and sialic acid, towards
normal physiological ranges. Molecular docking studies further revealed strong inhibitory interactions of quinoxaline with
MMP-2 and MMP-9, supporting its role in suppressing extracellular matrix degradation and tumor cell invasion.
Conclusion: Our findings demonstrate that quinoxaline exhibits potent anti-metastatic activity by modulating metastatic
biomarkers and inhibiting MMP activity, suggesting its potential as a promising therapeutic agent for the management of lung
cancer metastasis.

Item Type: Article
Uncontrolled Keywords: : Quinoxaline, lung metastasis, matrix metalloproteinases, anti-metastatic therapy, lung cancer, metastatic biomarkers
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 05 Mar 2026 06:50
Last Modified: 05 Mar 2026 08:47
URI: https://ir.psgcas.ac.in/id/eprint/2680

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