Loganathan Chandramani Priya Dharshini and Kunnathur Murugesan Sakthivel (2025) Targeting the redox neuroinfammatory nexus: insights into Alzheimer’s and Parkinson’s diseases. Targeting the redox neuroinfammatory nexus: insights into Alzheimer’s and Parkinson’s diseases, 33. pp. 3885-3895.

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Abstract

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s, are characterized by the progressive deterioration of
neuronal structure and function within the central and peripheral nervous systems. Among the multifactorial mechanisms
implicated in their pathogenesis, oxidative stress and chronic neuroinfammation have emerged as pivotal contributors. An
imbalance in redox homeostasis, marked by excessive generation of reactive oxygen species (ROS) and impaired antioxidant
defenses, leads to sustained activation of infammatory pathways and exacerbation of neuronal injury. This intricate interplay,
known as the redox–neuroinfammatory nexus, constitutes a central axis in the onset and progression of neurodegeneration.
This review underscores the critical role of redox imbalance in neurodegenerative processes and provides a comprehensive
analysis of the oxidative stress and infammation crosstalk in Alzheimer’s and Parkinson’s diseases, ofering insights into
potential therapeutic targets

Item Type: Article
Uncontrolled Keywords: Neurodegenerative disease · Alzheimer’s disease · Parkinson’s disease · Oxidative stress · Infammation
Divisions: PSG College of Arts and Science > Department of Biotechnology
PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 05 Mar 2026 08:55
Last Modified: 05 Mar 2026 08:55
URI: https://ir.psgcas.ac.in/id/eprint/2681

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