Kunnathur Murugesan Sakthivel and Rajan Radha Rasmi and Loganathan Chandramani Priya Dharshini and Balasubramanian Ramesh (2024) Systems biology approaches of Scopoletin reveal target potential biomarkers and its associated signaling pathways in colon cancer. Systems biology approaches of Scopoletin reveal target potential biomarkers and its associated signaling pathways in colon cancer, 12 (5). pp. 103-113.

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Abstract

Scopoletin (Sc) is a coumarin phytoalexin which is biosynthesized by numerous plants including Scopolia carniolica,
Scopolia japonica, Artemisia scoparia, and Viburnum prunifolium. The main goal of this study was to perform
a systemic bioinformatics on the anti-colon cancer effects of Scopoletin. A holistic bioinformatics strategy was
developed to predict the mechanisms by Sc that protects colon health. Comparative toxicogenomics database and
DisGeNET database were used to discover potential genes. The protein-protein interactions (PPIs) PPI network was
constructed using STRING and visualized by Cytoscape software. Based on a multi-pathway network using the
molecular complex detection plugin of Cytoscape, it was observed that Sc may protect colon cancer by suppressing
the oxidative stress and inhibiting inflammation through regulation of nuclear factor erythroid-related factor-2
signaling pathway, inflammation associated pathways, apoptosis pathway, autophagy pathway, cell proliferation
signaling, and insulin sensitizing pathway. Gene ontology analysis generates highly interconnected pathways that
are the basis for biological process, molecular function, and cellular components, as well as pathway enrichment
analysis. Our findings contributed to the investigation of molecular mechanisms and the identification of potential
target biomarkers for the treatment of colon cancer

Item Type: Article
Uncontrolled Keywords: Key words: Scopoletin, Colon cancer, Autophagy, Apoptosis, Systems biology and gene ontology.
Divisions: PSG College of Arts and Science > Department of Biotechnology
PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 25 Mar 2026 06:37
Last Modified: 25 Mar 2026 06:37
URI: https://ir.psgcas.ac.in/id/eprint/2731

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