Keerthana Manoharan (2024) Protective Effect of Ethanolic Extracts of Ananas Comosus and Vitis Vinifera Against Glucose Induced Cataract in Isolated Goat Lens. Protective Effect of Ethanolic Extracts of Ananas Comosus and Vitis Vinifera Against Glucose Induced Cataract in Isolated Goat Lens, 13 (3).

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Abstract

Background: Cataracts represent the significant basis of blindness worldwide that averts the
passage of light from the clear lens to the retina. The antioxidants present in natural sources
are known to delay the formation of cataracts. These antioxidants are the major constituents of
fruits. Materials and Methods: This study aimed to evaluate the fruits Ananas comosus and Vitis
vinifera for their antioxidant and anticataract activities against the cataract induced by glucose in
the freshly isolated goat lenses which was extracted by extracapsular method and were split into
six groups with six goat lenses each. Group I was the normal control, Group II was cataract control,
Group III was A. comosus extract treated lens, Groups IV and V were V. vinifera extract (green and
black grapes) treated respectively and Group VI was treated with the standard drug Enalapril.
The opacity of the lens was assessed after incubation and lens homogenate was evaluated for
antioxidant enzymes and also for lipid peroxidation. Results: The ethanolic fruit extracts of Ananas
comosus and Vitis vinifera showed significant antioxidant activity in In vitro methods and also
good anticataract activity in the isolated goat lens which could be caused by the action of the
phytochemicals. Conclusion: From the present study on the glucose induced cataractogenesis in
the isolated goat lenses, it can be concluded that the ethanolic fruit extracts of Ananas comosus
and Vitis vinifera exhibit significant antioxidant and anticataract activities.

Item Type: Article
Uncontrolled Keywords: Ananas comosus, Vitis vinifera, Antioxidants, Fruits, Cataract, Goat lens.
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 25 Mar 2026 08:24
Last Modified: 25 Mar 2026 08:24
URI: https://ir.psgcas.ac.in/id/eprint/2734

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