Keerthana Manoharan (2026) Anticancer activity of Illicium verum, Amomum subulatum and Parmotrema perlatum extracts against MCF-7 human breast cancer cell line. Anticancer activity of Illicium verum, Amomum subulatum and Parmotrema perlatum extracts against MCF-7 human breast cancer cell line, 21 (2).

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Abstract

Breast cancer remains one of the most widespread and lethal cancers among women worldwide, necessitating the development of more effective and less toxic therapeutic strategies. The study is aimed to assess the anticancer effect of combined extracts of Illicium verum, Amomum subulatum and Parmotrema perlatum on MCF-7 breast cancer cell lines using different assays. The ethanolic extracts of the spices were subjected to phytochemical analysis. In vitro antioxidant analysis was carried out to ascertain the effectiveness of combined extracts of spices compared to the individual extracts. The cytotoxicity of the combined extracts of I. verum, A. subulatum and P. perlatum was studied in the MCF-7 cell line by MTT, NRU and LDH assays. A variety of phytochemicals including phenolics, flavonoids, alkaloids, tannins and terpenoids were found to be present in the spice extracts. The combined extracts of the spices displayed significantly improved antioxidant activities in vitro when compared to the individual crude extracts.

Item Type: Article
Uncontrolled Keywords: Breast cancer, MCF-7 cell lines, Spices, Synergism, MTT assay.
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 25 Mar 2026 08:37
Last Modified: 25 Mar 2026 08:37
URI: https://ir.psgcas.ac.in/id/eprint/2735

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