Keerthana Manoharan and Victor Arokia Doss (2025) Quercetin inhibits steroid‑induced hypergluconeogenesis in Saccharomyces cerevisiae. Quercetin inhibits steroid‑induced hypergluconeogenesis in Saccharomyces cerevisiae. pp. 1-14.

[thumbnail of Springer Quercetin.pdf] Text
Springer Quercetin.pdf - Published Version
Download (1MB)

Abstract

Background Steroid-induced hypergluconeogenesis is a significant contributor to hyperglycemia, often complicating
the therapeutic use of steroids. This study investigates the potential of quercetin, a naturally occurring flavonoid,
to mitigate steroid-induced hypergluconeogenesis in Saccharomyces cerevisiae. The levels of glucose, total proteins,
free amino acids, pyruvate, lactate and antioxidants were assessed in the quercetin-treated yeast cells induced
with betamethasone at different time intervals. The glucose uptake potential of yeast cells treated with quercetin
was also studied and also the effect of steroids and quercetin on cell viability was analyzed.
Results Our results show that quercetin effectively reduces gluconeogenesis by normalizing the levels of metabolites
involved in the process and alleviates the hyperglycemic effects associated with steroid exposure. Quercetintreated
yeast cells also demonstrated a better uptake of glucose. Additionally, quercetin was found to improve
the overall cell viability highlighting its role in modulating glucose metabolism.
Conclusion These outcomes suggest that quercetin can serve as a promising adjunct therapy for managing steroid-
induced metabolic disturbances, providing a natural and effective approach to counteracting steroid-induced
hyperglycemia.

Item Type: Article
Uncontrolled Keywords: Steroids, Betamethasone, Gluconeogenesis, Saccharomyces cerevisiae, Glucose
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 25 Mar 2026 09:02
Last Modified: 25 Mar 2026 09:02
URI: https://ir.psgcas.ac.in/id/eprint/2736

Actions (login required)

View Item
View Item