Priya Dharshini, L C and Sathyabhama, Muthuswamy (2022) The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals. Biomolecules, 12: 1405. pp. 1-15.

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Abstract

Oxidative stress and mitochondrial dysfunction are associated with the pathogenesis of
several human diseases. The excessive generation of reactive oxygen species (ROS) and/or lack
of adequate antioxidant defenses causes DNA mutations in mitochondria, damages the mitochondrial respiratory chain, and alters membrane permeability and mitochondrial defense mechanisms.
All these alterations are linked to the development of numerous diseases. Curcumin, an active
ingredient of turmeric plant rhizomes, exhibits numerous biological activities (i.e., antioxidant, antiinflammatory, anticancer, and antimicrobial). In recent years, many researchers have shown evidence
that curcumin has the ability to reduce the oxidative stress- and mitochondrial dysfunction-associated
diseases. In this review, we discuss curcumin’s antioxidant mechanism and significance in oxidative stress reduction and suppression of mitochondrial dysfunction in mammals. We also discuss
the research gaps and give our opinion on how curcumin research in mammals should proceed
moving forward.

Item Type: Article
Uncontrolled Keywords: curcumin; mammals; mitochondrial dysfunction; oxidative stress; antioxidant; antiinflammatory; anticancer; antimicrobial
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 16 Mar 2023 09:50
Last Modified: 16 Mar 2023 09:50
URI: http://ir.psgcas.ac.in/id/eprint/1799

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